Macronutrient composition regulation of nutrient sensing factors and neurotransmitters affects anti-tumor immunity and subsequently HCC development

Abstract Cells alter their metabolic state in response to changes nutrient availability through the induction of transcriptional programs that affect levels transporters and enzymes. Cell-intrinsic mechanisms sensing are intimately linked adaptive responses play critical roles shaping complex dynamic environment a growing tumor. We aim understand how food composition, combination with alcohol consumption, impact host metabolism, development steatohepatitis induced hepatocellular carcinoma (HCC). further elucidated macronutrient dysbiosis, integrated influence HCC specifically axis immune cell status. Here we present diet chronic inflammation promotes bidirectional relationship between system systemic effector function cells, gut-liver-brain by neurotransmitter like serotonin GABA. This whole body metabolism immunometabolism drives immense humoral cellular response, development. Technologies such as Met-Flow, Mass spectrometry, FC scRNA/ATAC-seq were used for comprehensive analysis, conjunction long term intervention. In summary, show regulation pathways dietary intervention modulate immunoediting support tumor development, providing knowledge advance effective strategies treatment prevention U01AA027681